Pädiatrische Infektiologie & Immunologie / MRI Chronisches Fatigue Centrum (MCFC)

• First results of the "Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS)". Jakob CEM et al.. Infection. 2021 Feb;49(1):63-73.

• HCoV- and SARS-CoV-2 Cross-Reactive T Cells in CVID Patients. Steiner S et al.. Front Immunol. 2020 Dec 23;11:607918. 
• MYSM1 maintains ribosomal protein gene expression in hematopoietic stem cells to prevent hematopoietic dysfunction. Belle JI et al.. JCI Insight. 2020 Jul 9;5(13):e125690.
• Evaluation of T-activated proteins as recall antigens to monitor Epstein-Barr virus and human cytomegalovirus-specific T cells in a clinical trial setting. Körber N et al., J Transl Med. 2020 Jun 17;18(1):242.
• The Epstein-Barr Virus Major Tegument Protein BNRF1 Is a Common Target of Cytotoxic CD4+ T Cells. Adhikary D et al., J Virol. 2020 Jul 16;94(15):e00284-20.
• Identification and Cloning of a New Western Epstein-Barr Virus Strain That Efficiently Replicates in Primary B Cells. Delecluse S et al., J Virol. 2020 May 4;94(10):e01918-19.
• Differential upregulation of host cell protein kinases by the replication of α-, β- and γ-herpesviruses provides a signature of virus-specific signalling. Marschall M et al., J Gen Virol. 2020 Mar;101(3):284-289.

• Improvement of Guideline Adherence After the Implementation of an Antibiotic Stewardship Program in a Secondary Care Pediatric Hospital. Metz J et al., Front Pediatr. 2019 Nov 13;7:478.
• Plasma lipid profiles discriminate bacterial from viral infection in febrile children. Wang X et al.; EUCLIDS consortium. Sci Rep. 2019 Nov 27;9(1):17714.
• Spontaneous lymphoblastoid cell lines from patients with Epstein-Barr virus infection show highly variable proliferation characteristics that correlate with the expression levels of viral microRNAs. Delecluse S et al., PLoS One. 2019 Sep 30;14(9):e0222847.
• The German National Registry of Primary Immunodeficiencies (2012-2017). El-Helou SM et al., Front Immunol. 2019 Jul 19;10:1272.
• Epstein-Barr Virus Induces Expression of the LPAM-1 Integrin in B Cells In Vitro and In Vivo. Delecluse S et al., J Virol. 2019;93(5).
• Progress in EBV Vaccines. van Zyl DG et al. Front Oncol. 2019;9:104.
• Antibodies conjugated with viral antigens elicit a cytotoxic T cell response against primary CLL ex vivo. Schneidt V et al., Leukemia. 2019;33(1):88-98.
• Proteome Analysis of Human Neutrophil Granulocytes From Patients With Monogenic Disease Using Data-independent Acquisition. Grabowski P et al., Mol Cell Proteomics. 2019;18(4):760-772.

• Immunogenic particles with a broad antigenic spectrum stimulate cytolytic T cells and offer increased protection against EBV infection ex vivo and in mice. van Zyl DG et al., PLoS Pathog. 2018;14(12):e1007464.
• Clinical-grade generation of peptide-stimulated CMV/EBV-specific T cells from G-CSF mobilized stem cell grafts. Gary R et al., J Transl Med. 2018;16(1):124.
• Clinical implications of Epstein-Barr virus strain diversity. Cirac et al., J Immunological Sci. 2018; 2(3):51-55
• Epstein-Barr virus strain heterogeneity impairs human T-cell immunity. Cirac A et al., Cancer Immunol Immunother. 2018;67(4):663-674.
• Life-threatening infections in children in Europe (the EUCLIDS Project): a prospective cohort study. Martinón-Torres F et al.;EUCLIDS Consortium. Lancet Child Adolesc Health. 2018;2(6):404-414.
• Recommendations for Diagnostics and Therapy of Children with Cancer Presenting with Fever and Neutropenia - Comparison of Two Current Guidelines. Lehrnbecher T et al., Klin Padiatr. 2018;230(3):115-121.

• Epstein-Barr virus particles induce centrosome amplification and chromosomal instability. Shumilov A et al., Nat Commun. 2017;8:14257.
• A human immunodeficiency syndrome caused by mutations in CARMIL2. Schober T et al., Nat Commun. 2017;8:14209.
• Effective Immunological Guidance of Genetic Analyses Including Exome Sequencing in Patients Evaluated for Hemophagocytic Lymphohistiocytosis. Ammann S et al., HLH study of the GPOH. J Clin Immunol. 2017;37(8):770-780.
• Serological profiling of the EBV immune response in Chronic Fatigue Syndrome using a peptide microarray. Loebel M et al., PLoS One. 2017;12(6):e0179124.
• A human immunodeficiency syndrome caused by mutations in CARMIL2.
• The Epstein-Barr virus DNA load in the peripheral blood of transplant recipients does not accurately reflect the burden of infected cells. Fink S et al., Transpl Int. 2017;30(1):57-67.

• The Epstein-Barr virus DNA load in the peripheral blood of transplant recipients does not accurately reflect the burden of infected cells. Fink et al., Transplant International. 2016 Oct 7;
• Validation of an IFNγ/IL2 FluoroSpot assay for clinical trial monitoring. Körber N et al, J Transl Med. 2016;14(1):175.
• Diagnosis and Treatment of Nasopharyngeal Carcinoma in Children and Adolescents - Recommendations of the GPOH-NPC Study Group. Kontny U et al., Klin Padiatr. 2016;228(3):105-12.
• Epstein-Barr viral miRNAs inhibit antiviral CD4+ T cell responses targeting IL-12 and peptide processing. Tagawa T et al., J Exp Med. 2016;213(10):2065-80.
• A Diverse Repertoire of CD4 T Cells Targets the Immediate-Early 1 Protein of Human Cytomegalovirus. Ameres S et al., Front Immunol. 2015;6:598.
• Intrathecal CD8 T-cells of multiple sclerosis patients recognize lytic Epstein-Barr virus proteins. van Nierop GP et al., Mult Scler. 2016;22(3):279-91.

• Antigen-armed antibodies targeting B lymphoma cells effectively activate antigen-specific CD4+ T cells. Yu X et al., Blood. 2015;125(10):1601-10.
• Polyubiquitination of lysine-48 is an essential but indirect signal for MHC class I antigen processing. Fiebiger BM et al., Eur J Immunol. 2015;45(3):716-27.

• Virus and autoantigen-specific CD4+ T cells are key effectors in a SCID mouse model of EBV-associated post-transplant lymphoproliferative disorders. Linnerbauer S et al., PLoS Pathog. 2014;10(5):e1004068.
• Targeting high-grade B cell lymphoma with CD19-specific T cells. Lehmann FM et al., Int J Cancer. 2014;135(5):1153-64.
• Group-specific amplification of HLA-DQA1 revealed a number of genomic full-length sequences including the novel HLA alleles DQA1*01:10 and DQA1*01:11. Witter K et al., Tissue Antigens. 2014;83(1):49-51.
• The European Society for Immunodeficiencies (ESID) registry 2014. Grimbacher B et al.; ESID Registry Working Party. Clin Exp Immunol. 2014;178 Suppl 1:18-20.

2013

• Targeting c-MYC with T-cells. Helm F et al., PLoS One. 2013;8(10):e77375.
• Presentation of an immunodominant immediate-early CD8+ T cell epitope resists human cytomegalovirus immunoevasion.Ameres S et al., PLoS Pathog. 2013;9:e1003383.

2012

• Isolation of human MHC class II-restricted T cell receptors from the autologous T-cell repertoire with potent anti-leukaemic reactivity. Weigand LU et al., Immunology. 2012;137:226-38.
• Mature proteins derived from Epstein-Barr virus fail to feed into the MHC class I antigenic pool. Fiebiger BM et al. Eur J Immunol. 2012;42:3167-73.
• Humanized c-Myc mouse. Lehmann FM et al., PLoS One. 2012;7:e42021.
• Burkitt lymphoma: the role of Epstein-Barr virus revisited.Grömminger S et al., Br J Haematol. 2012;156:719-29. Review.
• Stromal interferon-γ signaling and cross-presentation are required to eliminate antigen-loss variants of B cell lymphomas in mice. Gerbitz A et al., PLoS One. 2012;7:e34552.
• The role of virus-specific CD4+ T cells in the control of Epstein-Barr virus infection.Mautner J & Bornkamm GW. Eur J Cell Biol. 2012;91:31-5.

2011

• Autophagy in herpesvirus immune control and immune escape.Taylor GS et al., Herpesviridae. 2011;2:2.
• Pancreatic cancers require autophagy for tumor growth. Yang S et al., Genes Dev. 2011;25:717-29.

2010

• Identification of MHC II-restricted minor histocompatibility antigens after HLA-identical stem-cell transplantation. Milosevic S et al., Transplantation. 2010;90:1030-5.
• Virus-specific cytotoxic CD4+ T cells for the treatment of EBV-related tumors. Merlo A et al., J Immunol. 2010;184:5895-902.
• Effective and long-term control of EBV PTLD after transfer of peptide-selected T cells. Moosmann A et al., Blood. 2010;115:2960-70.
• Epstein-Barr viruses that express a CD21 antibody provide evidence that gp350's functions extend beyond B-cell surface binding. Busse C et al., J Virol. 2010;84:1139-47.

2009

• An Epstein-Barr virus anti-apoptotic protein constitutively expressed in transformed cells and implicated in burkitt lymphomagenesis: the Wp/BHRF1 link. Kelly GL et al., PLoS Pathog. 2009;5:e1000341.
• Primary B-cell infection with a deltaBALF4 Epstein-Barr virus comes to a halt in the endosomal compartment yet still elicits a potent CD4-positive cytotoxic T-cell response. Neuhierl B et al. J Virol. 2009;83:4616-23.

2008

• Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells.Klibi J et al., Blood. 2009;113:1957-66. Contribution of viral recombinants to the study of the immune response against the Epstein-Barr virus.Delecluse HJ et al., Semin Cancer Biol. 2008;18:409-15. Review.
• Endogenous presentation of a nuclear antigen on MHC class II by autophagy in the absence of CRM1-mediated nuclear export.Riedel A et al., Eur J Immunol. 2008;38:2090-5.
• Standardized and highly efficient expansion of Epstein-Barr virus-specific CD4+ T cells by using virus-like particles. Adhikary D et al., J Virol. 2008;82:3903-11.
• A novel HLA-DRB1 allele, HLA-DRB1*0465, was identified in a Hodgkin's lymphoma cell line. Witter K et al., Tissue Antigens. 2008;71:257-8.
• Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Klionsky DJ et al. , Autophagy. 2008;4:151-75.

2007

• Immunodominance of lytic cycle antigens in Epstein-Barr virus-specific CD4+ T cell preparations for therapy. Adhikary D et al., PLoS One. 2007;2:e583.
• HLA-DQB1*0319, a novel HLA-DQB1 allele, shows strong haplotype association to HLA-DRB1*1102. Witter K et al., Tissue Antigens. 2007;70:73-5. 

2006

• Identification of major histocompatibility complex class II-restricted antigens and epitopes of the Epstein-Barr virus by a novel bacterial expression cloning approach. Milosevic S et al., J Virol. 2006;80:10357-64.
• Epstein-Barr virus BNRF1 protein allows efficient transfer from the endosomal compartment to the nucleus of primary B lymphocytes. Feederle R et al., J Virol. 2006;80:9435-43.
• The infectious kiss: newly infected B cells deliver Epstein-Barr virus to epithelial cells. Bornkamm GW et al., Proc Natl Acad Sci U S A. 2006;103:7201-2.
• Control of Epstein-Barr virus infection in vitro by T helper cells specific for virion glycoproteins. Adhikary D et al., J Exp Med. 2006;203:995-1006.
• Epstein-Barr virus vector-mediated gene transfer into human B cells: potential for antitumor vaccination. Hellebrand E et al., Gene Ther. 2006;13:150-62.

2005

• Direct mapping of MHC class II epitopes. Milosevic S et al., J Immunol Methods. 2005;306:28-39.
• Stringent doxycycline-dependent control of gene activities using an episomal one-vector system. Bornkamm GW et al., Nucleic Acids Res. 2005;33:e137.

• Epstein-Barr virus latent membrane protein 2A mimics B-cell receptor-dependent virus reactivation. Schaadt E et al., J Gen Virol. 2005;86:551-9.

• Diverse CD8+ T-cell responses to renal cell carcinoma antigens in patients treated with an autologous granulocyte-macrophage colony-stimulating factor gene-transduced renal tumor cell vaccine. Zhou X et al., Cancer Res. 2005;65:1079-88.
• Tumor-specific CD4+ T cells from a patient with renal cell carcinoma recognize diverse shared antigens. Mautner J et al., Int J Cancer. 2005;115:752-9.

2004

• Epstein-Barr virus nuclear antigen 1 evades direct immune recognition by CD4+ T helper cells. Mautner J et al., Eur J Immunol. 2004;34:2500-9.
• Active NF-kappaB signalling is a prerequisite for influenza virus infection. Nimmerjahn F et al., J Gen Virol. 2004;85:2347-56.

2003

• Efficient generation and expansion of antigen-specific CD4+ T cells by recombinant influenza viruses. Nimmerjahn F et al., Eur J Immunol. 2003;33:3331-41.
• Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries.Behrends U et al., Int J Cancer. 2003;106:244-51.
• Major histocompatibility complex class II-restricted presentation of a cytosolic antigen by autophagy. Nimmerjahn F et al., Eur J Immunol. 2003;33:1250-9.